Síndrome hemofagocítico secundario: reporte de 5 casos / Secondary hemophagocytic syndrome: report of 5 cases
Rev. méd. Chile
;
141(11): 1475-1479, nov. 2013. ilus, tab
Artículo
en Español
| LILACS
| ID: lil-704574
ABSTRACT
Secondary hemophagocytic syndrome (HFS) is an uncommon entity with a high mortality rate in adults, if no therapy is given. It is characterized by a severehipercytokinemia due to a highly stimulated but ineffective immune system. Theprincipal causes are infections, malignancy or autoimmune diseases. It appears asa serious illness, similar to a multiorgan failure. Treatment is not well defined. Wereport five patients with HFS, aged 17 to 51 years (three females). The etiology wasonco-hematological in three patients. In two patients, the diagnosis was performedduring necropsy. One case was due to cytomegalovirus (CMV) infection in a hepatictransplant patient and the other, due to parenteral lipid administration. All presentedfever, cytopenia, hepatosplenomegaly and hemophagocytosis. Four of them requiredadmission in an Intensive Care Unit. All received different treatment modalities. Onlyone survived. Median survival time was 75 days. In conclusion, HFS has differentetiologies and a high mortality in adults.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Infecciones por Citomegalovirus
/
Linfohistiocitosis Hemofagocítica
/
Soluciones para Nutrición Parenteral
/
Lípidos
/
Linfoma
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2013
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Hospital del Salvador/CL
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