Importancia de la tiroglobulina sérica preablativa en la predicción de sobrevida libre de enfermedad en cáncer diferenciado de tiroides / Preablative serum thyroglobulin as predictor of disease-free survival in differentiated thyroid cancer
Rev. méd. Chile
;
141(12): 1506-1511, dic. 2013. graf, tab
Artículo
en Español
| LILACS
| ID: lil-705568
ABSTRACT
Background:
Serum thyroglobulin (sTg) is an excellent marker of persistence or recurrence of disease in differentiated thyroid cancer (DTC), however its role as prognostic factor has not been fully established.Aim:
To assess the value of the preablative thyroglobulin (pTg) as predictor of disease-free survival in DTC. Patients andMethods:
Retrospective study of 104 patients with low and intermediate risk DTC subjected to total thyroidectomy and 131iodine ablation. TSH, pTg and thyroglobulin antibodies (AbTg) were determined by chemiluminescence. Patients with distant metastases or presence of AbTg were excluded. Results were analyzed using receiving operating characteristic (ROC) curves.Results:
During the 40 ± 29 months of follow-up (range 6-132), 14 of 104 (13%) patients had recurrence of disease. pTg was an independent indicator to predict disease-free survival. Using a pTg cutoff of < 10 ng/ml the negative predictive value was 99%, sensitivity 93%, specificity 82%, positive likelihood ratio (LR) 5.2 and negative LR 0,087.Conclusions:
pTg value is useful as a prognostic marker in predicting disease-free survival in DTC patients with low or intermediate risk of recurrence.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Tiroglobulina
/
Neoplasias de la Tiroides
/
Carcinoma
/
Biomarcadores de Tumor
/
Recurrencia Local de Neoplasia
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Chile
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2013
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Hospital del Salvador/CL
Similares
MEDLINE
...
LILACS
LIS