Notch ligand Delta-like 1 promotes the metastasis of melanoma by enhancing tumor adhesion
Braz. j. med. biol. res
;
47(4): 299-306, 8/4/2014. graf
Artículo
en Inglés
| LILACS
| ID: lil-705762
ABSTRACT
Notch signaling plays a vital role in tumorigenicity and tumor progression by regulating proliferation, invasion, and the tumor microenvironment. Previous research by our group indicated that Notch ligand Delta-like 1 (Dll1) is involved in angiogenesis in melanoma, and we noticed that it took a longer time to trypsinize Dll1-expressing B16 melanoma cells than the control cells. In this article, we extended our study to investigate the effects of Dll1 on tumor cell adhesion and metastasis. Dll1 overexpression activated Notch signaling in B16 tumor cells and significantly enhanced the adhering capacity of B16 tumor cells both in vitro and in vivo. B16-Dll1 cells also had a higher metastatic potential than their counterpart in the mouse model of lung metastasis. Along with increased Dll1 expression, N-cadherin, but not E-cadherin, was upregulated in B16-Dll1 cells. These data suggested that Notch ligand Dll1 may enhance the adhesion and metastasis of melanoma cells by upregulation of N-cadherin.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Melanoma Experimental
/
Transducción de Señal
/
Cadherinas
/
Péptidos y Proteínas de Señalización Intercelular
/
Neoplasias Pulmonares
/
Proteínas de la Membrana
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
2014
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
China
Institución/País de afiliación:
The Fourth Military Medical University/CN
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