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Benefits and risks of testosterone treatment for hypoactive sexual desire disorder in women: a critical review of studies published in the decades preceding and succeeding the advent of phosphodiesterase type 5 inhibitors
Reis, Sandra Léa Bonfim; Abdo, Carmita H.N..
  • Reis, Sandra Léa Bonfim; Universidade de São Paulo. Faculdade de Medicina. Department of Pathophysiology. São Paulo. BR
  • Abdo, Carmita H.N.; Universidade de São Paulo. Faculdade de Medicina. Department of Pathophysiology. São Paulo. BR
Clinics ; 69(4): 294-303, 4/2014. tab, graf
Artículo en Inglés | LILACS | ID: lil-705775
ABSTRACT
With advancing age, there is an increase in the complaints of a lack of a libido in women and erectile dysfunction in men. The efficacy of phosphodiesterase type 5 inhibitors, together with their minimal side effects and ease of administration, revolutionized the treatment of erectile dysfunction. For women, testosterone administration is the principal treatment for hypoactive sexual desire disorder. We sought to evaluate the use of androgens in the treatment of a lack of libido in women, comparing two periods, i.e., before and after the advent of the phosphodiesterase type 5 inhibitors. We also analyzed the risks and benefits of androgen administration. We searched the Latin-American and Caribbean Health Sciences Literature, Cochrane Library, Excerpta Medica, Scientific Electronic Library Online, and Medline (PubMed) databases using the search terms disfunção sexual feminina/female sexual dysfunction, desejo sexual hipoativo/female hypoactive sexual desire disorder, testosterona/testosterone, terapia androgênica em mulheres/androgen therapy in women, and sexualidade/sexuality as well as combinations thereof. We selected articles written in English, Portuguese, or Spanish. After the advent of phosphodiesterase type 5 inhibitors, there was a significant increase in the number of studies aimed at evaluating the use of testosterone in women with hypoactive sexual desire disorder. However, the risks and benefits of testosterone administration have yet to be clarified.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Testosterona / Disfunciones Sexuales Psicológicas / Andrógenos Tipo de estudio: Estudio de etiología Límite: Adolescente / Adulto / Femenino / Humanos Idioma: Inglés Revista: Clinics Asunto de la revista: Medicina Año: 2014 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade de São Paulo/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Testosterona / Disfunciones Sexuales Psicológicas / Andrógenos Tipo de estudio: Estudio de etiología Límite: Adolescente / Adulto / Femenino / Humanos Idioma: Inglés Revista: Clinics Asunto de la revista: Medicina Año: 2014 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade de São Paulo/BR