The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms
Mem. Inst. Oswaldo Cruz
;
109(3): 362-364, 06/2014. graf
Artículo
en Inglés
| LILACS
| ID: lil-711731
ABSTRACT
Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi. Two of these compounds (6 and 7) showed better activity against both proliferative stages of T. cruzi than the positive control benznidazole, three were of similar potency (1, 2 and 5) and two were less active (3 and 4).
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Tripanocidas
/
Trypanosoma cruzi
/
Diaminas
/
Amino Alcoholes
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2014
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Centro de Pesquisas René Rachou-Fiocruz/BR
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