Neurotoxicidad secundaria a metronidazol: un efecto adverso reversible. Caso clínico / Reversible neurotoxicity secondary to metronidazole report of one case
Rev. méd. Chile
; 142(3): 386-390, mar. 2014. ilus
Article
en Es
| LILACS
| ID: lil-714364
Biblioteca responsable:
CL1.1
ABSTRACT
Metronidazole can cause adverse effects both in the central and peripheral nervous system. We report a 34-year-old female who presented a reversible cerebellar syndrome and peripheral neuropathy as an adverse effect associated with the use of metronidazole. Brain magnetic resonance imaging (MRI) showed hyperintense T2 and FLAIR bilateral symmetrical cerebellar lesions, without contrast enhancement or mass effect, isointense in diffusion-weighted imaging and hypointense in apparent diffusion coefficient sequences. Also, electrophysiological evaluation was consistent with axonal polyneuropathy. She had received metronidazole for a liver abscess during 49 days. After discontinuation of metronidazole, she had rapid regression of cerebellar symptoms and normalization of MRI, with subsequent disappearance of peripheral symptoms. The brain MRI, electromyography and nerve conduction studies performed at 35 months later showed complete resolution of the lesions. Although metronidazole neurotoxicity is a rare event, it must be borne in mind because the prognosis is usually favorable after stopping the drug.
Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Enfermedades Cerebelosas
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Enfermedades del Sistema Nervioso Periférico
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Metronidazol
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Antiprotozoarios
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Female
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Humans
Idioma:
Es
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
2014
Tipo del documento:
Article