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Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil
Capobiango, Jaqueline Dario; Breganó, Regina Mitsuka; Navarro, Italmar Teodorico; Rezende Neto, Claudio Pereira; Casella, Antônio Marcelo Barbante; Mori, Fabiana Maria Ruiz Lopes; Pagliari, Sthefany; Inoue, Inácio Teruo; Reiche, Edna Maria Vissoci.
Afiliación
  • Capobiango, Jaqueline Dario; Universidade Estadual de Londrina. Health Sciences Center. Department of Clinical Medicine. Londrina. BR
  • Breganó, Regina Mitsuka; Universidade Estadual de Londrina. Health Sciences Center. Department of Clinical Medicine. Londrina. BR
  • Navarro, Italmar Teodorico; Universidade Estadual de Londrina. Health Sciences Center. Department of Clinical Medicine. Londrina. BR
  • Rezende Neto, Claudio Pereira; Universidade Estadual de Londrina. Health Sciences Center. Department of Clinical Medicine. Londrina. BR
  • Casella, Antônio Marcelo Barbante; Universidade Estadual de Londrina. Health Sciences Center. Department of Clinical Medicine. Londrina. BR
  • Mori, Fabiana Maria Ruiz Lopes; Universidade Estadual de Londrina. Health Sciences Center. Department of Clinical Medicine. Londrina. BR
  • Pagliari, Sthefany; Universidade Estadual de Londrina. Health Sciences Center. Department of Clinical Medicine. Londrina. BR
  • Inoue, Inácio Teruo; Universidade Estadual de Londrina. Health Sciences Center. Department of Clinical Medicine. Londrina. BR
  • Reiche, Edna Maria Vissoci; Universidade Estadual de Londrina. Health Sciences Center. Department of Clinical Medicine. Londrina. BR
Braz. j. infect. dis ; Braz. j. infect. dis;18(4): 364-371, Jul-Aug/2014. tab
Article en En | LILACS | ID: lil-719297
Biblioteca responsable: BR1.1
ABSTRACT
This study describes the characteristics of 31 children with congenital toxoplasmosis children admitted to the University Hospital of Londrina, Southern Brazil, from 2000 to 2010. In total, 23 (85.2%) of the mothers received prenatal care but only four (13.0%) were treated for toxoplasmosis. Birth weight was <2500 g in 37.9% of the infants. During the first month of life, physical examination was normal in 34.5%, and for those with clinical signs and symptoms, the main manifestations were hepatomegaly and/or splenomegaly (62.1%), jaundice (13.8%), and microcephaly (6.9%). During ophthalmic examination, 74.2% of the children exhibited injuries, 58.1% chorioretinitis, 32.3% strabismus, 19.4% microphthalmia, and 16.2% vitreitis. Anti-Toxoplasma gondii IgM antibodies were detected in 48.3% of the children. Imaging brain evaluation was normal in 44.8%; brain calcifications, hydrocephaly, or both conditions were observed in 27.6%, 10.3%, and 17.2%, respectively, of the patients. Patients with cerebrospinal fluid protein > 200 mg/dL presented more brain calcifications (p = 0.0325). Other sequelae were visual impairment (55.2% of the cases), developmental delay (31.0%), motor deficit (13.8%), convulsion (27.5%), and attention deficit (10.3%). All patients were treated with sulfadiazine, pyrimethamine, and folinic acid, and 55.2% of them exhibited adverse effects. The results demonstrate the significance of the early diagnosis and treatment of toxoplasmosis during pregnancy to reduce congenital toxoplasmosis and its consequences.
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Texto completo: 1 Índice: LILACS Asunto principal: Toxoplasma / Anticuerpos Antiprotozoarios / Toxoplasmosis Congénita Tipo de estudio: Observational_studies / Risk_factors_studies / Screening_studies Límite: Adolescent / Adult / Child / Female / Humans / Male / Newborn / Pregnancy País/Región como asunto: America do sul / Brasil Idioma: En Revista: Braz. j. infect. dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2014 Tipo del documento: Article

Texto completo: 1 Índice: LILACS Asunto principal: Toxoplasma / Anticuerpos Antiprotozoarios / Toxoplasmosis Congénita Tipo de estudio: Observational_studies / Risk_factors_studies / Screening_studies Límite: Adolescent / Adult / Child / Female / Humans / Male / Newborn / Pregnancy País/Región como asunto: America do sul / Brasil Idioma: En Revista: Braz. j. infect. dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2014 Tipo del documento: Article