The remarkable journey of adaptation of the Plasmodium falciparum malaria parasite to New World anopheline mosquitoes
Mem. Inst. Oswaldo Cruz
;
109(5): 662-667, 19/08/2014. graf
Artículo
en Inglés
| LILACS
| ID: lil-720425
ABSTRACT
Plasmodium falciparum originated in Africa, dispersed around the world as a result of human migration and had to adapt to several different indigenous anopheline mosquitoes. Anophelines from the New World are evolutionary distant form African ones and this probably resulted in a more stringent selection of Plasmodium as it adapted to these vectors. It is thought that Plasmodium has been genetically selected by some anopheline species through unknown mechanisms. The mosquito immune system can greatly limit infection and P. falciparum evolved a strategy to evade these responses, at least in part mediated by Pfs47, a highly polymorphic gene. We propose that adaptation of P. falciparum to new vectors may require evasion of their immune system. Parasites with a Pfs47 haplotype compatible with the indigenous mosquito vector would be able to survive and be transmitted. The mosquito antiplasmodial response could be an important determinant of P. falciparum population structure and could affect malaria transmission in the Americas.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Plasmodium falciparum
/
Insectos Vectores
/
Anopheles
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2014
Tipo del documento:
Artículo
País de afiliación:
Estados Unidos
Institución/País de afiliación:
National Institutes of Health/US
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