Asociación entre obesidad y cáncer de ovario / Association between obesity and ovarian cancer
Rev. méd. Chile
;
142(5): 593-598, mayo 2014. ilus, tab
Artículo
en Español
| LILACS
| ID: lil-720668
ABSTRACT
Obesity is a risk factor for cancer. Epidemiological evidences associate ovarian cancer with obesity. Epithelial ovarian cancer (EOC) is the most common type of ovarian cancer and accounts for a high rate of mortality. The association between ovarian cancer and obesity could be explained by molecular factors secreted by adipose tissue such as leptin. In EOC, leptin increases cell proliferation and inhibits apoptosis. Additionally, adipose tissue synthesizes endogenous estrogens, which increase cell proliferation of epithelial ovarian cells. Also, obesity associated hyperinsulinism could increase ovarian estrogen secretion.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Neoplasias Ováricas
/
Obesidad
Tipo de estudio:
Factores de riesgo
Límite:
Femenino
/
Humanos
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2014
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Universidad Diego Portales/CL
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