Prevalence of microbiological markers in bone tissue from live and cadaver donors in the musculoskeletal tissue bank of Passo Fundo / Prevalência de marcadores microbiológicos em tecido ósseo de doadores e cadáveres do Banco de Tecidos Musculoesqueléticos de Passo Fundo

ABSTRACT

Objective: To conduct an epidemiological analysis on the main microbiological markers in bone tissue that was processed at the musculoskeletal tissue bank of Hospital São Vicente de Paulo, in Passo Fundo, between August 2007 and October 2011. Methods: Between August 2007 and October 2011, 202 musculoskeletal tissue samples were collected for the tissue bank. Among these, 159 samples were from living donor patients and 43 were from cadaver donors. The following serological tests were requested: hepatitis B, hepatitis C, syphilis, cytomegalovirus, Chagas disease, toxoplasmosis, HIV and HTLV. Results: Among the 159 living donors, 103 (64.75%) were men and 56 (35.25%) were women. The patients' mean age was 59.35 ± 8.87 years. Out of this total, 76 tissue samples (47.8%) from donors were rejected. There was no difference in the number of rejections in relation to sex (p = 0.135) or age (p = 0.523). The main cause of rejection was serologically positive findings for the hepatitis B virus, which was responsible for 48 rejections (63.15%). Among the 43 cadaver donors, the mean age was 37.84 ± 10.32 years. Of these, 27 (62.8%) were men and 16 (37.2%) were women. Six of the samples collected from cadaver donors were rejected (13.9%), and the main cause of rejection was serologically positive findings for the hepatitis C virus, which was responsible for three cases (50%). There was no significant difference in the number of rejections in relation to sex (p = 0.21) or age (p = 0.252). Conclusion: There were a greater number of rejections of tissues from living donors (47.8%) than from cadaver donors (13.9%). Among the living donors, the main cause of rejection was the presence of serologically positive findings of the hepatitis B virus, while among the cadaver donors, it was due to the hepatitis C virus...

RESUMO

Objetivo: Fazer uma análise epidemiológica dos principais marcadores microbiólogicos dos tecidos ósseos processados de agosto de 2007 a outubro de 2011 no Banco de Tecidos Musculoesqueléticos do Hospital São Vicente de Paulo de Passo Fundo. Métodos: Foram feitas 202 captações de tecidos musculoesqueléticos para o Banco de Tecidos. Desse total, 159 foram de doadores e 43 de cadáveres. Foram solicitados testes sorológicos para hepatite B, hepatite C, sífilis, citomegalovírus, doença de Chagas, toxoplasmose, HIV e HTLV. Resultados: Dos 159 doadores, 103 (64,75%) eram do sexo masculino e 56 (35,25%) do feminino. A idade média foi de 59,35 ± 8,87 anos. Foram descartados 76 (47,8%) tecidos de doadores. Não houve diferença significativa no número de descartes em relação a sexo (p = 0,135) ou idade (p = 523). A principal causa de descarte foi a sorologia positiva para o vírus da hepatite B, responsável por 48 (63,15%) descartes. Já entre os 43 cadáveres, a média de idade foi de 37,84 ± 10,32 anos. Desses, 27 (62,8%) eram do sexo masculino e 16 (37,2%) do feminino. Foram descartados seis (13,9%) cadáveres. A principal causa de descarte foi a sorologia positiva para o vírus da hepatite C, responsável por três (50%) casos. Não houve diferença significativa no número de descartes em relação a sexo (p = 0,21) ou idade (p = 252). Conclusão: Houve um número maior de descarte de tecidos de doadores (47,8%) em comparação com os cadáveres (13,9%). Nos doadores, a principal causa de descarte foi a presença de sorologia positiva para o vírus da hepatite B; nos cadáveres, para o vírus da hepatite C...