Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
Mem. Inst. Oswaldo Cruz
;
109(7): 948-951, 11/2014. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-728801
ABSTRACT
The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax isolates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Plasmodium vivax
/
Variación Genética
/
Resistencia a Medicamentos
/
Cloroquina
/
ADN Protozoario
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Humanos
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2014
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal do Rio de Janeiro/BR
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