Interferon-γ inhibits group B Streptococcus survival within human endothelial cells
Mem. Inst. Oswaldo Cruz
; 109(7): 940-943, 11/2014. graf
Article
en En
| LILACS
| ID: lil-728811
Biblioteca responsable:
BR1.1
ABSTRACT
Endothelial dysfunction is a major component of the pathophysiology of septicaemic group B Streptococcus (GBS) infections. Although cytokines have been shown to activate human umbilical vein endothelial cells (HUVECs), the capacity of interferon (IFN)-γ to enhance the microbicidal activity of HUVECs against GBS has not been studied. We report that the viability of intracellular bacteria was reduced in HUVECs activated by IFN-γ. Enhanced fusion of lysosomes with bacteria-containing vacuoles was observed by acid phosphatase and the colocalisation of Rab-5, Rab-7 and lysosomal-associated membrane protein-1 with GBS in IFN-γ-activated HUVECs. IFN-γ resulted in an enhancement of the phagosome maturation process in HUVECs, improving the capacity to control the intracellular survival of GBS.
Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Infecciones Estreptocócicas
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Streptococcus agalactiae
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Interferón gamma
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Viabilidad Microbiana
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Células Endoteliales de la Vena Umbilical Humana
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Antiinfecciosos
Límite:
Humans
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Año:
2014
Tipo del documento:
Article