Interferon-γ inhibits group B Streptococcus survival within human endothelial cells
Mem. Inst. Oswaldo Cruz
;
109(7): 940-943, 11/2014. graf
Artículo
en Inglés
| LILACS
| ID: lil-728811
ABSTRACT
Endothelial dysfunction is a major component of the pathophysiology of septicaemic group B Streptococcus (GBS) infections. Although cytokines have been shown to activate human umbilical vein endothelial cells (HUVECs), the capacity of interferon (IFN)-γ to enhance the microbicidal activity of HUVECs against GBS has not been studied. We report that the viability of intracellular bacteria was reduced in HUVECs activated by IFN-γ. Enhanced fusion of lysosomes with bacteria-containing vacuoles was observed by acid phosphatase and the colocalisation of Rab-5, Rab-7 and lysosomal-associated membrane protein-1 with GBS in IFN-γ-activated HUVECs. IFN-γ resulted in an enhancement of the phagosome maturation process in HUVECs, improving the capacity to control the intracellular survival of GBS.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Infecciones Estreptocócicas
/
Streptococcus agalactiae
/
Interferón gamma
/
Viabilidad Microbiana
/
Células Endoteliales de la Vena Umbilical Humana
/
Antiinfecciosos
Límite:
Humanos
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2014
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal do Rio de Janeiro/BR
Similares
MEDLINE
...
LILACS
LIS