Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
36(4): 277-284, Oct-Dec/2014. tab
Artículo
en Inglés
| LILACS
| ID: lil-730596
ABSTRACT
Objective:
To ascertain whether genetic variations in the serotonin transporter gene (5-HTTLPR 44-bp insertion/deletion polymorphism) influence an increase in depressive and anxiety symptoms in children and adolescents exposed to high levels of violence.Methods:
Saliva samples were collected from a group of children who were working on the streets and from their siblings who did not work on the streets. DNA was extracted from the saliva samples and analyzed for 5-HTTLPR polymorphism genotypes.Results:
One hundred and seventy-seven children between the ages of 7 and 14 years were analyzed (114 child workers and 63 siblings). Data on socioeconomic conditions, mental symptoms, and presence and severity of maltreatment and urban violence were collected using a sociodemographic inventory and clinical instruments. There was no positive correlation between the 5-HTTLPR polymorphism and presence of mental symptoms in our sample, although the children were exposed to high levels of abuse, neglect, and urban violence.Conclusions:
Despite previous studies that associated adult psychiatric disorders with the 5-HTTLPR polymorphism and a history of childhood maltreatment, no such association was found in this sample of children at risk. .
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Trastornos de Ansiedad
/
Maltrato a los Niños
/
Trastorno Depresivo
/
Proteínas de Transporte de Serotonina en la Membrana Plasmática
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio pronóstico
/
Investigación cualitativa
/
Estudio de tamizaje
Límite:
Adolescente
/
Niño
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Asunto de la revista:
Psiquiatria
Año:
2014
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal de São Paulo (UNIFESP)/BR
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