Histological investigation of the effect of soybean (Glycine max) extracts on the collagen layer and estrogen receptors in the skin of female rats
Clinics
; 69(12): 854-861, 2014. tab, graf
Article
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| LILACS
| ID: lil-732391
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ABSTRACT
OBJECTIVES:
The purpose of this study was to analyze the effects of soybean extracts obtained using different extraction methods on the skin of female rats.METHOD:
A total of 64 female Sprague-Dawley rats were divided into 8 equal groups. Various extracts were administered to the female rats by oral gavage for one month. The groups comprised carboxymethyl cellulose-free control, carboxymethyl cellulose-plus control, 100-mg/kg n-hexane extract, 200-mg/kg n-hexane extract, 100-mg/kg ethyl acetate extract, 200-mg/kg ethyl acetate extract, 100-mg/kg ethanol extract and 200-mg/kg ethanol extract groups. The thickness of the collagen layer and the number of estrogen receptor-positive cells were evaluated.RESULTS:
All the extract-treated groups showed a statistically significant decrease in the number of estrogen receptor-positive cells compared with the control groups. Regarding the thickness of the collagen layer, only the 200-mg/kg ethyl acetate extract-treated group showed a significant increase compared with the control groups (p<0.05).CONCLUSIONS:
Our data suggest that oral intake of three different total soybean extracts might have positive estrogenic effects on the skin and that only a high-dose ethyl acetate extract can increase the expression of collagen, which may prove to be beneficial for postmenopausal facial skin. ...Palabras clave
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Índice:
LILACS
Asunto principal:
Piel
/
Glycine max
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Extractos Vegetales
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Receptores de Estrógenos
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Colágeno
Límite:
Animals
Idioma:
En
Revista:
Clinics
Asunto de la revista:
MEDICINA
Año:
2014
Tipo del documento:
Article