Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction
Acta cir. bras
;
30(1): 73-79, 01/2015. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-735708
ABSTRACT
PURPOSE:
To evaluate the influence of glutamine and obstructive jaundice on left colon healing in rats.METHODS:
Sixteen male rats were allocated across four groups LG - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct ligation until euthanasia. L - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. M - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. MG - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct manipulation until euthanasia. On the day of euthanasia, bursting pressure of the sutured bowel segment was measured and samples were collected for histopathological analysis.RESULTS:
There were no differences in bursting pressure among groups LG vs. M (110 ± 28 vs. 173 ± 12; p = 0.08). Groups L and MG were not different from group M (156 ± 12 and 118 ± 22. Glutamine supplementation was associated with less edema, polymorphonuclear lymphocyte infiltration, bacterial colonies, and abscess formation, as well as with increased collagen formation.CONCLUSION:
Obstructive jaundice had no negative effect and glutamine supplementation had no positive effect on colonic scar strength in rats. .
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Cicatrización de Heridas
/
Colestasis Extrahepática
/
Colon
/
Ictericia Obstructiva
/
Glutamina
Tipo de estudio:
Estudios de evaluación
/
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2015
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Brasilia University/BR
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