Effects of blocking αvβ3 integrin by a recombinant RGD disintegrin on remodeling of wound healing after induction of incisional hernia in rats
Acta cir. bras
; 30(2): 134-142, 02/2015. graf
Article
en En
| LILACS
| ID: lil-741023
Biblioteca responsable:
BR1.1
ABSTRACT
PURPOSE:
To investigate the changes induced by DisBa-01 on repair of wound healing after induced incisional hernia (IH) in rats.METHODS:
Thirty two male albino rats were submitted to IH and divided into four experimental groups G1, placebo control; G2, DisBa-01-treated; G3, anti-αvβ3 antibodies-treated and G4, anti-α2 antibodies-treated. Histological, biochemical and extracellular matrix remodeling analysis of abdominal wall were evaluated.RESULTS:
After 14 days, 100% of the G2 did not present hernia, and the hernia ring was closed by a thin membrane. In contrast, all groups maintained incisional hernia. DisBa-01 also increased the number macrophages and fibroblasts and induced the formation of new vessels. Additionally, MMP-2 was strongly activated only in G2 (p<0.05). Anti- αvβ3-integrin antibodies produced similar results than DisBa-01 but not anti-α2 integrin blocking antibodies.CONCLUSION:
DisBa-01 has an important role in the control of wound healing and the blocking of this integrin may be an interesting therapeutically strategy in incisional hernia. .Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Cicatrización de Heridas
/
Inhibidores de Agregación Plaquetaria
/
Desintegrinas
/
Hernia Ventral
Tipo de estudio:
Prognostic_studies
/
Systematic_reviews
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2015
Tipo del documento:
Article