Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance
Mem. Inst. Oswaldo Cruz
;
110(1): 101-105, 03/02/2015. tab, graf
Artículo
en Inglés
| LILACS, ColecionaSUS, CONASS
| ID: lil-741611
ABSTRACT
The 2009 pandemic influenza A virus outbreak led to the systematic use of the neuraminidase (NA) inhibitor oseltamivir (OST). Consequently, OST-resistant strains, carrying the mutation H275Y, emerged in the years after the pandemics, with a prevalence of 1-2%. Currently, OST-resistant strains have been found in community settings, in untreated individuals. To spread in community settings, H275Y mutants must contain additional mutations, collectively called permissive mutations. We display the permissive mutations in NA of OST-resistant A(H1N1)pdm09 virus found in Brazilian community settings. The NAs from 2013 are phylogenetically distinct from those of 2012, indicating a tendency of positive selection of NAs with better fitness. Some previously predicted permissive mutations, such as V241I and N369K, found in different countries, were also detected in Brazil. Importantly, the change D344N, also predicted to compensate loss of fitness imposed by H275Y mutation, was found in Brazil, but not in other countries in 2013. Our results reinforce the notion that OST-resistant A(H1N1)pdm09 strains with compensatory mutations may arise in an independent fashion, with samples being identified in different states of Brazil and in different countries. Systematic circulation of these viral strains may jeopardise the use of the first line of anti-influenza drugs in the future. (AU)
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Virus de la Influenza A
/
Farmacorresistencia Viral
/
Oseltamivir
Tipo de estudio:
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Año:
2015
Tipo del documento:
Artículo
Institución/País de afiliación:
Instituto Oswaldo Cruz/BR
/
Instituto de Pesquisas Clínicas Evandro Chagas/BR
/
Laboratório de Vírus Respiratórios e do Sarampo/BR
/
Minas Gerais (Estado). Secretaria de Estado da Saúde/BR
/
Paraná (Estado) Secretaria de Estado da Saúde/BR
/
Rio Grande do Sul (Estado). Secretaria de Estado da saúde/BR
/
Santa Catarina (Estado). Secretaria de Estado da Saúde/BR
Similares
MEDLINE
...
LILACS
LIS