Insulin-like growth factor (IgF)-I, IgF binding protein-3, and prostate cancer: correlation with gleason score
Int. braz. j. urol
;
41(1): 110-115, jan-feb/2015. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-742883
ABSTRACT
Introduction Non-androgenic growth factors are involved in the growth regulation of prostate cancer (PCa). Objective This is the first Brazilian study to correlate, in a population of patients operated for PCa, PSA, total testosterone, insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-3 (IGFBP-3) with Gleason score and to compare with a control group with benign prostate hyperplasia (BPH). Materials and Methods This retrospective single-center study included 49 men with previously diagnosed PCa and 45 with previously diagnosed BPH. PSA, testosterone, IGF-I, IGFBP-3 were determined in both groups. Results PSA and IGFBP-3 levels were significantly higher in the PCa group as compared to the BPH group (p<0.001 and p=0.004, respectively). There was a significant difference when we compared the PSA before surgery (p<0.001) and at the inclusion in the study (p<0.001) and IGFBP3 (0.016) among patients with Gleason <7, ≥7 and BPH. In the PCa group, PSA, testosterone, IGF-I and IGFBP-3 levels were comparable between Gleason <7 and ≥7. Conclusions Our data suggest that in localized PCa, the quantification of PSA and, not of IGF-1, may provide independent significant information in the aggressiveness. IGFBP-3 could be a biochemical marker of disease control in PCa patients. .
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
/
Diferenciación Celular
/
Trastorno Depresivo
/
Contaminantes Atmosféricos
/
Nanopartículas
Tipo de estudio:
Estudio de etiología
Límite:
Animales
/
Femenino
/
Humanos
/
Masculino
/
Embarazo
Idioma:
Inglés
Revista:
Int. braz. j. urol
Asunto de la revista:
Urología
Año:
2015
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal do Rio de Janeiro/BR
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