The role of necroptosis in neurosurgical diseases
Braz. j. med. biol. res
;
48(4): 292-298, 4/2015.
Artículo
en Inglés
| LILACS
| ID: lil-744365
ABSTRACT
Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Lesiones Encefálicas
/
Trastornos Cerebrovasculares
/
Apoptosis
/
Receptores de Muerte Celular
/
Necrosis
Límite:
Humanos
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
2015
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
China
Institución/País de afiliación:
Shanghai Jiaotong University/CN
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