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Thyroid disorders are common in first-degree relatives of individuals with type 1 diabetes mellitus
Araujo, Débora Batista; Barone, Bianca; Melleti, Natasha Ferreira Teixeira; Dantas, Joana Rodrigues; Oliveira, Marcus Miranda dos Santos; Zajdenverg, Lenita; Tortora, Rosangela Prendim; Vaisman, Mario; Milech, Adolpho; Oliveira, José Egídio Paulo de; Rodacki, Melanie.
  • Araujo, Débora Batista; Federal University of Rio de Janeiro. Diabetes and Nutritional Diseases Section. Department of Internal Medicine. Rio de Janeiro. BR
  • Barone, Bianca; Federal University of Rio de Janeiro. Diabetes and Nutritional Diseases Section. Department of Internal Medicine. Rio de Janeiro. BR
  • Melleti, Natasha Ferreira Teixeira; Federal University of Rio de Janeiro. Diabetes and Nutritional Diseases Section. Department of Internal Medicine. Rio de Janeiro. BR
  • Dantas, Joana Rodrigues; Federal University of Rio de Janeiro. Diabetes and Nutritional Diseases Section. Department of Internal Medicine. Rio de Janeiro. BR
  • Oliveira, Marcus Miranda dos Santos; Federal University of Rio de Janeiro. Diabetes and Nutritional Diseases Section. Department of Internal Medicine. Rio de Janeiro. BR
  • Zajdenverg, Lenita; Federal University of Rio de Janeiro. Diabetes and Nutritional Diseases Section. Department of Internal Medicine. Rio de Janeiro. BR
  • Tortora, Rosangela Prendim; Federal University of Rio de Janeiro. Diabetes and Nutritional Diseases Section. Department of Internal Medicine. Rio de Janeiro. BR
  • Vaisman, Mario; Federal University of Rio de Janeiro. Diabetes and Nutritional Diseases Section. Department of Internal Medicine. Rio de Janeiro. BR
  • Milech, Adolpho; Federal University of Rio de Janeiro. Diabetes and Nutritional Diseases Section. Department of Internal Medicine. Rio de Janeiro. BR
  • Oliveira, José Egídio Paulo de; Federal University of Rio de Janeiro. Diabetes and Nutritional Diseases Section. Department of Internal Medicine. Rio de Janeiro. BR
  • Rodacki, Melanie; Federal University of Rio de Janeiro. Diabetes and Nutritional Diseases Section. Department of Internal Medicine. Rio de Janeiro. BR
Arch. endocrinol. metab. (Online) ; 59(2): 112-115, 04/2015. tab
Artículo en Inglés | LILACS | ID: lil-746456
ABSTRACT
Objective Thyroid diseases are common in individuals with type 1 diabetes mellitus (T1DM) and should be investigated annually in these individuals. The aim of this study was to evaluate the frequency of thyroid diseases in first degree relatives (FDR) of patients with T1DM. Subjects and methods Eighty individuals (40 patients with T1DM and 40 FDR) were interviewed and blood was sampled for thyroid-stimulating hormone (TSH), free thyroxine (FT4) and thyroid peroxidase (TPO) antibodies measurement. Autoantibodies against glutamic acid decarboxylase 65 (GAD65), islet antigen-2 (IA2) and autoantibodies against insulin (AAI) were measured in FDR. Results We found a similar prevalence of thyroid dysfunction in patients with T1DM and their FDR (22.5% vs. 27.5%; p = 0,79). There were no differences in serum TSH levels (p = 0.29), FT4 (p = 0,45), frequency of abnormal TSH (p = 0.28), positive TPO antibodies (p = 0.13), titers of TPO antibodies (in positive cases) between patients with T1DM and their FDR (p = 0.94). Conclusions Thyroid abnormalities seem to be common not only in patients with T1DM but also in their FDR, which suggests that screening strategies for thyroid diseases might also be useful to these individuals. .
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Enfermedades de la Tiroides / Diabetes Mellitus Tipo 1 Tipo de estudio: Estudio de prevalencia / Factores de riesgo Límite: Adolescente / Adulto / Niño / Femenino / Humanos / Masculino Idioma: Inglés Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: Endocrinologia / Metabolismo Año: 2015 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Federal University of Rio de Janeiro/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Enfermedades de la Tiroides / Diabetes Mellitus Tipo 1 Tipo de estudio: Estudio de prevalencia / Factores de riesgo Límite: Adolescente / Adulto / Niño / Femenino / Humanos / Masculino Idioma: Inglés Revista: Arch. endocrinol. metab. (Online) Asunto de la revista: Endocrinologia / Metabolismo Año: 2015 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Federal University of Rio de Janeiro/BR