Effects of vardenafil on the kidney of Wistar rats submitted to acute ischemia and reperfusion
Acta cir. bras
;
30(5): 339-344, 05/2015. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-747023
ABSTRACT
PURPOSE:
To investigate the effect of vardenafil in kidney of rats submitted to acute ischemia and reperfusion.METHODS:
Twenty-eight rats were randomly distributed into two groups. Right nephrectomy was performed and the vardenafil group received vardenafil solution (at a concentration of 1 mg/ml in 10 mg/kg) while the control group received 0.9% saline solution (SS) one hour prior to the ligature of the left renal pedicle. After one hour of ischemia, animals were submitted to twenty-four hours of reperfusion, followed by left nephrectomy. The kidney's histological parameters evaluated on the study included vacuolar degeneration and tubular necrosis. Apoptosis was assessed by immunohistochemistry for cleaved caspase-3 using the point-counting and digital methods (Cytophotometry). Also, a biochemical analysis for creatinine was conducted.RESULTS:
There were statistically significant differences between groups only with regards to the vacuolar degeneration parameter and to the cleaved caspase-3 digital method.CONCLUSION:
Vardenafil showed a protective effect on the kidney of rats subjected to acute ischemia and reperfusion in this model .
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Piperazinas
/
Daño por Reperfusión
/
Imidazoles
/
Isquemia
/
Riñón
Tipo de estudio:
Estudios de evaluación
/
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2015
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Mogi das Cruzes University/BR
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