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Inhibition of pyruvate dehydrogenase by methotrexate
Arq. biol. tecnol ; 32(2): 391-5, jun. 1989. ilus
Artículo en Inglés | LILACS | ID: lil-74930
ABSTRACT
The effect of methotrexate (MTX) on the activity of pyruvate dehydrogenase from liver mitochondria and from the crude extract of HeLa cells was studied. the activity of the enzyme from liver mitochondria was 50% inhibited with 800nmoles MTX/mg of protein and the enzyme from vrude extract of HeLa cells was 50% inhibited with only 60 nmoles MTX/mg of protein. The specific activity of the former was 0.75nmoles NAD+ reduced.min-1. meg-1 and the latter 0.48nmoles NAD+ reduced.minmg-1
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Índice: LILACS (Américas) Asunto principal: Metotrexato / Piruvato Deshidrogenasa (Lipoamida)-Fosfatasa Idioma: Inglés Revista: Arq. biol. tecnol Asunto de la revista: Biologia / Biotecnologia Año: 1989 Tipo del documento: Artículo

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Índice: LILACS (Américas) Asunto principal: Metotrexato / Piruvato Deshidrogenasa (Lipoamida)-Fosfatasa Idioma: Inglés Revista: Arq. biol. tecnol Asunto de la revista: Biologia / Biotecnologia Año: 1989 Tipo del documento: Artículo