The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury
Acta cir. bras
;
30(6): 414-421, 06/2015. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-749644
ABSTRACT
PURPOSE:
To investigate the protective effect of dexmedetomidine (Dex) on testicular damage induced by ischemia-reperfusion injury in rats.METHODS:
Sham group underwent left scrotal exploration only (group 1). The ischemia-reperfusion only group underwent left testicular torsion and detorsion (group 2). The ischemia-reperfusion plus Dex group underwent left testicular torsion, received 50 µg/kg Dex (group 3) and 100 µg/kg Dex (group 4) intraperitoneally at minute 180 of ischemia and then underwent detorsion. We determined histopathological findings and performed specific biochemical analyses.RESULTS:
Increasing doses of Dex significantly increased TAS, and significantly decreased OSI. Analyzing the antioxidant effects of increasing doses of Dex in torsion and contrlateral testicles Dex 100 µg/kg statistically significant increased the tissue total antioxidant status (TAS) and oxidative stress index (OSI) when compared with Dex 50 µg/kg but not found significantly change on the tissue total oxidant status (TOS). However, Dex did not significantly improve these histological alterations.CONCLUSION:
The antioxidant effects of dexmedetomidine on testicular ischemia-reperfusion injury in ipsilateral and contrlateral testis, but in the histopathological level, there was no difference statistically according to Johnsen's scoring system between groups at both sides. .
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Torsión del Cordón Espermático
/
Testículo
/
Daño por Reperfusión
/
Dexmedetomidina
/
Antioxidantes
Tipo de estudio:
Estudios de evaluación
/
Estudio observacional
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2015
Tipo del documento:
Artículo
País de afiliación:
Turquía
Institución/País de afiliación:
University of Kirikkale/TR
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