Hemoglobin H disease caused by two gene deletions
Braz. j. med. biol. res
;
22(6): 675-81, June 1989. ilus
Artículo
en Inglés
| LILACS
| ID: lil-75156
ABSTRACT
1. A white Brazilian woman not of Asian origin was found to have Hb H disease of moderate severity. 2. Gene mapping demonstrated that the disease was caused by the association of two abnormal alfa-globin gene clusters on chromosome 16 one with a deletion which removed the two function alfa genes and the other carryng the 3.7-Kb rightward deletion, which leaves functional alfa gene. 3. These data ilustrate the necessity for systematic molecular approaches to the diagnosis of this heterogeneous group of diseases
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Índice:
LILACS (Américas)
Asunto principal:
Talasemia
/
Cromosomas Humanos Par 16
/
Deleción Cromosómica
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1989
Tipo del documento:
Artículo
/
Documento de proyecto
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