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Field validation of a Leishmania (Leishmania) mexicana exo-antigens ELISA for diagnosing tegumentary leishmaniasis in regions of Leishmania (Viannia) predominance
Soares, Killarney Ataide; Urdapilleta, Ada Amália Ayala; Santos, Gilcilene Maria dos; Carneiro, Andréa Lisboa; Gomes, Ciro Martins; Roselino, Ana Maria; Sampaio, Raimunda Nonata Ribeiro.
  • Soares, Killarney Ataide; Universidade de Brasília. Brasília. BR
  • Urdapilleta, Ada Amália Ayala; Universidade de Brasília. Brasília. BR
  • Santos, Gilcilene Maria dos; Universidade de Brasília. Brasília. BR
  • Carneiro, Andréa Lisboa; Universidade de Brasília. Brasília. BR
  • Gomes, Ciro Martins; Universidade de Brasília. Brasília. BR
  • Roselino, Ana Maria; Universidade de Brasília. Brasília. BR
  • Sampaio, Raimunda Nonata Ribeiro; Universidade de Brasília. Brasília. BR
Braz. j. infect. dis ; 19(3): 302-307, May-Jun/2015. tab, graf
Artículo en Inglés | LILACS | ID: lil-751876
ABSTRACT

Background:

Several tests are performed to obtain better accuracy when diagnosing American tegumentary leishmaniasis (ATL). It is believed that antigens released via secretion, excretion and metabolism are more specific than are antigens released by the lysis of Leishmania parasites. Such antigens are known as exo-antigens (exo-Ag) and are formed from products released by cultured parasites in a way that is similar to that in which they cause infections in hosts.

Objective:

We attempted to validate a Leishmania mexicana ELISA exo-Ag for ATL diagnosis in Midwestern Brazil.

Methods:

A total of 281 patients were included in the study. We analysed pre-treatment blood from 98 ATL patients; out of those, 85.7% and 14.3% had cutaneous and mucosal forms, respectively.

Results:

The exo-Ag accuracy was 83.99% (95% CI = 79.24-87.81) with a sensitivity value of 90.82% (95% CI = 83.46-95.09) and an overall specificity value of 80.33% (95% CI = 73.97-85.44). The positive predictive value and negative predictive value were 71.20% (95% CI = 62.72-78.41) and 94.23% (95% CI = 89.40-96.94), respectively. Among healthy controls, exo-Ag had a specificity of 91.25% (95% CI = 83.02-95.70); additionally, the test had specificity rates of 66.67% (95% CI = 46.71-82.03) in Chagas disease patients, 60.61% (95% CI = 43.68-75.32) in patients with rheumatic diseases, 76.92% (95% CI = 49.74-91.82) in pemphigus foliaceus patients, 87.50% (95% CI = 52.91-97.76) in leprosy patients, 87.50% (95% CI = 63.98-96.50) in VRDL-positive patients, and 77.78 (95% CI = 45.26-93.68) in deep mycosis patients.

Conclusion:

Based on the indicators of validity, we conclude that the results obtained in this study enable the recommendation of the exo-Ag ELISA for ATL diagnosis once it presented a reasonable accuracy compared to classical methods. Cost evaluations are necessary to completely define the role of this technique in large scale. .
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Leishmania braziliensis / Leishmania mexicana / Ensayo de Inmunoadsorción Enzimática / Leishmaniasis Cutánea / Antígenos de Protozoos Tipo de estudio: Estudio diagnóstico / Guía de Práctica Clínica / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adolescente / Adulto / Anciano / Femenino / Humanos / Masculino País/Región como asunto: México Idioma: Inglés Revista: Braz. j. infect. dis Asunto de la revista: Enfermedades Transmisibles Año: 2015 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Brasil Institución/País de afiliación: Universidade de Brasília/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Leishmania braziliensis / Leishmania mexicana / Ensayo de Inmunoadsorción Enzimática / Leishmaniasis Cutánea / Antígenos de Protozoos Tipo de estudio: Estudio diagnóstico / Guía de Práctica Clínica / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adolescente / Adulto / Anciano / Femenino / Humanos / Masculino País/Región como asunto: México Idioma: Inglés Revista: Braz. j. infect. dis Asunto de la revista: Enfermedades Transmisibles Año: 2015 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Brasil Institución/País de afiliación: Universidade de Brasília/BR