Involvement of eicosanoids and PAF in immune-coplex alveolitis
Braz. j. med. biol. res
;
22(6): 745-8, June 1989. tab, ilus
Artículo
en Inglés
| LILACS
| ID: lil-75219
ABSTRACT
An immune-complex-mediated hypersensitivity reaction induced in the rat lung was followed by release of the eicosanoids thromboxane, prostaglandin E2 and leukotriene B4 into bronchoalveolar space. Concomitantly, there was a decrease in the number of circulating platelets. The thrombocytopenia was inhibited by a cyclo-oxygenase inhibitor (indomethacin), a platelet activating factor (PAF) antagonist (BN-52021) and an inhibitor of thromboxane (econazozle), but was not affected by a lipoxygenase inhibitor (NDGA). These results suggest the involvement of eicosanoids and PAF in the immune complex hypersensitivity reaction in the rat lung and indicate the ocurrence of interactions between PAF and thromboxane
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Índice:
LILACS (Américas)
Asunto principal:
Líquido del Lavado Bronquioalveolar
/
Factor de Activación Plaquetaria
/
Tromboxanos
/
Alveolitis Alérgica Extrínseca
/
Complejo Antígeno-Anticuerpo
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1989
Tipo del documento:
Artículo
/
Congreso y conferencia
/
Documento de proyecto
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