The role of immunohistochemistry in the Muir-Torre Syndrome
An. bras. dermatol
;
90(3,supl.1): 168-170, May-June 2015. ilus
Artículo
en Inglés
| LILACS
| ID: lil-755731
ABSTRACT
Muir-Torre Syndrome is defined by the coexistence of sebaceous skin tumors and internal malignancies. Mutations in the DNA mismatch repair genes are found in the inherited form of the disease, resulting in the absence of crucial enzymes involved with DNA replication process. This case describes a patient with sebaceous adenoma and colorectal carcinoma, meeting the criteria for Muir-Torre Syndrome. The immunohistochemical analysis of the skin lesion was an important tool to confirm the diagnosis, as it revealed nuclear negativity for MSH2 and MSH6.
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Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Inmunohistoquímica
/
Carcinoma
/
Neoplasias Colorrectales
/
Síndrome de Muir-Torre
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
An. bras. dermatol
Asunto de la revista:
Dermatologia
Año:
2015
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal do Amazonas/BR
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