Botulinum toxin type A on cutaneous flap viability in diabetic and tobacco-exposed rats
Acta cir. bras
;
30(9): 639-645, Sep. 2015. tab, ilus
Artículo
en Inglés
| LILACS
| ID: lil-761498
ABSTRACT
PURPOSE:
To investigate the effect of Botulinum toxin A (BoNTA) on skin flap viability in healthy, tobacco-exposed and diabetic rats.METHODS:
Ninety male Wistar rats (250-300g) were randomly divided into six groups control+saline (C1), control+BoNTA (C2), tobacco-exposed+saline (T1), tobacco-exposed+BoNTA (T2) diabetes+saline (D1) and diabetes+BoNTA (D2). A dorsal cutaneous flap (3×10cm) was performed. Survival area and total area of the flaps were measured. Lumen diameter, external arterial diameter and lumen/wall thickness ratio were recorded.RESULTS:
Survival area increased in control group with BoNTA injection compared with control animals injected with saline (C2 x C1; 0.9±0.1 vs0.67±0.15, p= 0.001). A similar result was found in diabetes group injected with BontA (D2 x D1; 0.97±0.2 vs0.61±0.24, p=0.018). No difference was observed in skin flap viability in tobacco-exposed groups (T2 x T1; 0.74±0.24 vs 0.64±0.21, p=0.871). Lumen diameter (p= 0.004), external arterial diameter (p = 0.0046,) and lumen/wall thickness ratio (p= 0.003) were increased in diabetes+BoNTA-treated animals. This effect was not observed in control or in tobacco-exposed groups.CONCLUSIONS:
Botulinum toxin A increased skin flap viability in control and diabetic rats on the seventh post-operative day. Increased lumen diameter, external arterial diameter, and lumen/wall thickness ratio were observed in the diabetes+BoNTA group. BoNTA had no effect in the tobacco-exposed group on the seventh postoperative day.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Piel
/
Colgajos Quirúrgicos
/
Contaminación por Humo de Tabaco
/
Toxinas Botulínicas Tipo A
/
Diabetes Mellitus Experimental
/
Fármacos Neuromusculares
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudios de evaluación
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2015
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de São Paulo/BR
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