Whole-genome sequencing of a Plasmodium vivax isolate from the China-Myanmar border area
Mem. Inst. Oswaldo Cruz
;
110(6): 814-816, Sept. 2015. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-763088
ABSTRACT
Currently, there is a trend of an increasing number of Plasmodium vivaxmalaria cases in China that are imported across its Southeast Asia border, especially in the China-Myanmar border area (CMB). To date, little is known about the genetic diversity of P. vivaxin this region. In this paper, we report the first genome sequencing of a P. vivaxisolate (CMB-1) from a vivax malaria patient in CMB. The sequencing data were aligned onto 96.43% of the P. vivaxSalvador I reference strain (Sal I) genome with 7.84-fold coverage as well as onto 98.32% of 14 Sal I chromosomes. Using the de novoassembly approach, we generated 8,541 scaffolds and assembled a total of 27.1 Mb of sequence into CMB-1 scaffolds. Furthermore, we identified all 295 known virgenes, which is the largest subtelomeric multigene family in malaria parasites. These results provide an important foundation for further research onP. vivaxpopulation genetics.
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Índice:
LILACS (Américas)
Asunto principal:
Plasmodium vivax
/
ADN Protozoario
/
Análisis de Secuencia de ADN
/
Genoma de Protozoos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2015
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
China
Institución/País de afiliación:
National Institute of Parasitic Diseases/CN
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