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Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseases
Matos, Daniel Mazza; Furtado, Felipe Magalhães; Falcão, Roberto Passetto.
Afiliación
  • Matos, Daniel Mazza; Universidade de São Paulo. Ribeirão Preto. BR
  • Furtado, Felipe Magalhães; Universidade de São Paulo. Ribeirão Preto. BR
  • Falcão, Roberto Passetto; Universidade de São Paulo. Ribeirão Preto. BR
Rev. bras. hematol. hemoter ; Rev. bras. hematol. hemoter;37(5): 292-295, Sept.-Oct. 2015. tab, graf
Article en En | LILACS | ID: lil-764217
Biblioteca responsable: BR408.1
Ubicación: BR408.1
ABSTRACT

BACKGROUND:

Monoclonal B-cell lymphocytosis is classified as 'high-count or clinical' monoclonal B-cell lymphocytosis and 'low-count or population' monoclonal B-cell lymphocytosis. Previously, 167 first-degree relatives pertaining to sporadic (non-familial) chronic lymphocytic leukemia families were studied and the presence of seven monoclonal B-cell lymphocytosis individuals was reported.

OBJECTIVE:

The aim of this report is to describe the outcomes of five of the original monoclonal B-cell lymphocytosis individuals.

METHODS:

Flow cytometry analysis was performed on mononuclear cells previously isolated from peripheral blood samples. A strategy of sequential gating designed to identify the population of CD19+/CD5+ B-lymphocytes was used and, subsequently, the monoclonal B-cell lymphocytosis cells were characterized by the CD20weak/CD79bweak/negative phenotype.

RESULTS:

The monoclonal B-cell lymphocytosis clone showed consistent stability over time with little variations in size. After a median follow-up of 7.6 years, none of the five monoclonal B-cell lymphocytosis individuals progressed to chronic lymphocytic leukemia or other B-cell lymphoproliferative disease.

CONCLUSIONS:

The data of this study suggest that chronic lymphocytic leukemia-like monoclonal B-cell lymphocytosis detected in the context of sporadic chronic lymphocytic leukemia families is not prone to clinical evolution and could be just a sign of immune senescence.
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Texto completo: 1 Índice: LILACS Asunto principal: Linfocitos B / Leucemia de Células B / Leucemia Linfocítica Crónica de Células B / Relaciones Familiares / Citometría de Flujo / Linfocitosis / Trastornos Linfoproliferativos / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Rev. bras. hematol. hemoter Asunto de la revista: HEMATOLOGIA Año: 2015 Tipo del documento: Article

Texto completo: 1 Índice: LILACS Asunto principal: Linfocitos B / Leucemia de Células B / Leucemia Linfocítica Crónica de Células B / Relaciones Familiares / Citometría de Flujo / Linfocitosis / Trastornos Linfoproliferativos / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Rev. bras. hematol. hemoter Asunto de la revista: HEMATOLOGIA Año: 2015 Tipo del documento: Article