Adenosine: an endogenous mediator in the pathogenesis of psoriasis
An. bras. dermatol
; An. bras. dermatol;90(6): 862-867, Nov.-Dec. 2015. graf
Article
en En
| LILACS
| ID: lil-769527
Biblioteca responsable:
BR1.1
ABSTRACT
Abstract It is known that inflammatory and immune responses protect us from the invasion of micro-organisms and eliminate "wastes" from the injured sites, but they may also be responsible for significant tissue damage. Adenosine, as a purine nucleoside, which is produced in inflamed or injured sites, fulfills its role in limiting tissue damage. Although, it may have a pleiotropic effect, which signals it with a proinflammatory state in certain situations, it can be considered a potent anti-inflammatory mediator. The effects of adenosine, which acts through its receptors on T cell, on mast cell and macrophages, on endothelial cells, on neutrophils and dendritic cells, as they indicate TNF-alpha and cytokines, show that this mediator has a central role in the pathogenesis of psoriasis. The way it acts in psoriasis will be reviewed in this study.
Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Psoriasis
/
Adenosina
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
An. bras. dermatol
Asunto de la revista:
DERMATOLOGIA
Año:
2015
Tipo del documento:
Article