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Effect of collagen sponge and fibrin glue on bone repair
SANTOS, Thiago de Santana; ABUNA, Rodrigo Paolo Flores; ALMEIDA, Adriana Luisa Gonçalves de; BELOTI, Marcio Mateus; ROSA, Adalberto Luiz.
  • SANTOS, Thiago de Santana; Universidade de São Paulo. Faculdade de Odontologia de Ribeirão Preto. Laboratório de Cultura de Células. Ribeirão Preto. BR
  • ABUNA, Rodrigo Paolo Flores; Universidade de São Paulo. Faculdade de Odontologia de Ribeirão Preto. Laboratório de Cultura de Células. Ribeirão Preto. BR
  • ALMEIDA, Adriana Luisa Gonçalves de; Universidade de São Paulo. Faculdade de Odontologia de Ribeirão Preto. Laboratório de Cultura de Células. Ribeirão Preto. BR
  • BELOTI, Marcio Mateus; Universidade de São Paulo. Faculdade de Odontologia de Ribeirão Preto. Laboratório de Cultura de Células. Ribeirão Preto. BR
  • ROSA, Adalberto Luiz; Universidade de São Paulo. Faculdade de Odontologia de Ribeirão Preto. Laboratório de Cultura de Células. Ribeirão Preto. BR
J. appl. oral sci ; 23(6): 623-628, Nov.-Dec. 2015. graf
Artículo en Inglés | LILACS, BBO | ID: lil-769815
ABSTRACT
ABSTRACT The ability of hemostatic agents to promote bone repair has been investigated using in vitro and in vivo models but, up to now, the results are inconclusive. Objective In this context, the aim of this study was to compare the potential of bone repair of collagen sponge with fibrin glue in a rat calvarial defect model. Material and Methods Defects of 5 mm in diameter were created in rat calvariae and treated with either collagen sponge or fibrin glue; untreated defects were used as control. At 4 and 8 weeks, histological analysis and micro-CT-based histomorphometry were carried out and data were compared by two-way ANOVA followed by Student-Newman-Keuls test when appropriated (p≤0.05). Results Three-dimensional reconstructions showed increased bone formation in defects treated with either collagen sponge or fibrin glue compared with untreated defects, which was confirmed by the histological analysis. Morphometric parameters indicated the progression of bone formation from 4 to 8 weeks. Additionally, fibrin glue displayed slightly higher bone formation rate when compared with collagen sponge. Conclusion Our results have shown the benefits of using collagen sponge and fibrin glue to promote new bone formation in rat calvarial bone defects, the latter being discreetly more advantageous.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Osteogénesis / Regeneración Ósea / Hemostáticos / Adhesivo de Tejido de Fibrina / Colágeno Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: J. appl. oral sci Asunto de la revista: Odontología Año: 2015 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade de São Paulo/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Osteogénesis / Regeneración Ósea / Hemostáticos / Adhesivo de Tejido de Fibrina / Colágeno Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: J. appl. oral sci Asunto de la revista: Odontología Año: 2015 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade de São Paulo/BR