Could CD64 expression be used as a predictor of positive culture results in children with febrile neutropenia?
Rev. bras. hematol. hemoter
;
37(6): 395-399, Oct.-Dec. 2015. tab
Artículo
en Inglés
| LILACS
| ID: lil-769976
ABSTRACT
Background:
Early recognition of infectious processes in neutropenic patients is hampered by the fact that these processes may have dissimilar and non-specific clinical presentations. CD64 is a neutrophil surface marker that is not expressed in non-sensitized neutrophils. When the neutrophil is exposed to tumor necrosis factor-alpha it is activated and is measured via the CD64 index.Methods:
This paper evaluated the relationship between the index value of CD64 on the first day of febrile neutropenia and a positive blood culture. The correlations with white blood count, C-reactive protein and erythrocyte sedimentation rate were also evaluated. This case-control, prospective, diagnostic study included 64 episodes of neutropenia. Case group (n = 14) comprised positive blood cultures, and the control group (n = 50), negative blood cultures.Results:
The median rates of CD64 were 2.1 (a ± 3.9) in the case group and 1.76 (a ± 5.02) in the control group. There was no correlation between the value of the CD64 index and blood cultures. The CD64 index was also not correlated with C-reactive protein positivity. Further- more, the CD64 index was not able to predict blood culture positivity. The sensitivity was 64.3%, the specificity was 42%, the positive predictive value was 23.7% and the negative predictive value was 80%. For C-reactive protein, the sensitivity, specificity, positive predictive value, and negative predictive value were 71.4%, 32%, 22.7%, and 80%, respectively.Conclusion:
The CD64 index is not suitable for predicting the positivity of blood cultures in this specific population of patients with febrile neutropenia.
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Índice:
LILACS (Américas)
Asunto principal:
Proteína C-Reactiva
/
Receptores de IgG
/
Sepsis
/
Neutropenia Febril
/
Citometría de Flujo
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
Límite:
Adolescente
/
Niño
/
Humanos
Idioma:
Inglés
Revista:
Rev. bras. hematol. hemoter
Asunto de la revista:
Hematología
Año:
2015
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Pontifícia Universidade Católica de Rio Grande do Sul/BR
/
Universidade Federal de Ciências da Saúde de Porto Alegre/BR
/
Universidade Federal do Rio Grande do Sul (UFRGS)/BR
/
Universidade Federal do Rio Grande do Sul/BR
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