Variantes de hemoglobina en una población con impresión diagnóstica positiva para hemoglobinopatías en Colombia / Hemoglobin variants in Colombian patients referred to discard hemoglobinopathies
Rev. méd. Chile
;
143(10): 1260-1268, oct. 2015. graf, tab
Artículo
en Español
| LILACS
| ID: lil-771709
ABSTRACT
Background:
Oxygen transport is altered in hemoglobinopathies.Aim:
To study the distribution of hemoglobinopathies in Andean subjects without African ancestry. Material andMethods:
We analyzed blood samples of 1,407 subjects aged 18 to 59 years (58% females), living in the central Andean region of Colombia, referred to discard hemoglobinopathies. The frequency and type of hemoglobinopathy was established by capillary and agarose gel electrophoresis.Results:
The frequency of hemoglobinopathies was 34.5% and higher among females. The structural variants found were AS-heterozygous hemoglobin (8.1%), homozygous SS (3.7%), heterozygous SC (2.2%), AC heterozygotes (0.5%) and heterozygous AE (0.3%). Quantitative variants found were Hb A-Beta thalassemia (13.91%) and Hb H (0.06%), Beta-thalassemia heterozygotes C (0.88%), S-Beta thalassemia heterozygotes (6.07%) and compound heterozygous SC/Beta thalassemia (0.25%), with a persistence of fetal hemoglobin 0. Composite thalassemia was also found in 31%. All techniques showed good correlation and capillary electrophoresis demonstrated a greater detection of hemoglobin variants.Conclusions:
The frequency of hemoglobin variants in the analyzed population was high, which is an important public health indicator. The most common hemoglobin variant was HbA/Increased structural Hb A2 and the mos frequent structural hemoglobinopathy was sickle cell trait. Capillary electrophoresis can discern any Hb variants present in the population.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Hemoglobinas
/
Hemoglobinopatías
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Colombia
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2015
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Colombia
Institución/País de afiliación:
Hospital Militar Central/CO
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