Comparison of the effects of magnesium and ketamine on postoperative pain and morphine consumption. A double-blind randomized controlled clinical study
Acta cir. bras
;
31(1): 67-73, Jan. 2016. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-771846
ABSTRACT
PURPOSE: To compare the effects of magnesium sulfate and ketamine on postoperative pain and total morphine consumption in a placebo-controlled design. METHODS: One hundred and twenty women scheduled for total abdominal hysterectomy were included in this prospective, randomized, double-blind study. Postoperatively, when the Numeric Pain Rating Scale (NPRS) was four or more, IV-PCA morphine was applied to all patients. The patients were randomized into three groups: Group K ketamine, Group M magnesium, and Group C saline received as infusion. Total morphine consumption for 48h, pain scores, adverse effects, and patients' satisfaction were evaluated. RESULTS: Total morphine consumption was significantly lower in Group K (32.6±9.2 mg) than in Group M (58.9±6.5 mg) and in Group C (65.7±8.2 mg). The satisfaction level of patients in Group K was higher than the other two groups (p<0.05). Pruritus and nausea were observed more frequently in Group C. CONCLUSİON: The addition of ketamine to IV-PCA morphine reduces the total consumption of morphine without psychotic effects; however, magnesium did not influence morphine consumption.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Dolor Postoperatorio
/
Manejo del Dolor
/
Analgésicos
/
Analgésicos Opioides
/
Ketamina
/
Sulfato de Magnesio
/
Morfina
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio observacional
Límite:
Anciano
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2016
Tipo del documento:
Artículo
País de afiliación:
Turquía
Institución/País de afiliación:
Karabuk University/TR
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