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Active anti-acetylcholinesterase component of secondary metabolites produced by the endophytic fungi of Huperzia serrata
Wang, Zhejian; Ma, Zhao; Wang, Lili; Tang, Chengchen; Hu, Zhibi; Chou, GuiXin; Li, Wankui.
  • Wang, Zhejian; Shanghai University of Traditional Chinese Medicine. Institute of Traditional Chinese Medicine. Shanghai. CN
  • Ma, Zhao; Shanghai University of Traditional Chinese Medicine. Institute of Traditional Chinese Medicine. Shanghai. CN
  • Wang, Lili; Shanghai University of Traditional Chinese Medicine. Institute of Traditional Chinese Medicine. Shanghai. CN
  • Tang, Chengchen; Shanghai University of Traditional Chinese Medicine. Institute of Traditional Chinese Medicine. Shanghai. CN
  • Hu, Zhibi; Shanghai University of Traditional Chinese Medicine. Institute of Traditional Chinese Medicine. Shanghai. CN
  • Chou, GuiXin; Shanghai University of Traditional Chinese Medicine. Institute of Traditional Chinese Medicine. Shanghai. CN
  • Li, Wankui; Shanghai University of Traditional Chinese Medicine. Institute of Traditional Chinese Medicine. Shanghai. CN
Electron. j. biotechnol ; 18(6): 399-405, Nov. 2015. ilus, graf, tab
Artículo en Inglés | LILACS | ID: lil-772282
ABSTRACT
Background An endophytic fungus lives within a healthy plant during certain stages of, or throughout, its life cycle. Endophytic fungi do not always cause plant disease, and they include fungi that yield different effects, including mutual benefit, and neutral and pathogenic effects. Endophytic fungi promote plant growth, improve the host plant's resistance to biotic and abiotic stresses, and can produce the same or similar biologically active substances as the host. Thus, endophytic fungal products have important implications in drug development. Result Among the numerous endophytic fungi, we identified two strains, L10Q37 and LQ2F02, that have anti-acetylcholinesterase activity, but the active compound was not huperzine A. The aim of this study was to investigate the anti-acetylcholinesterase activity of secondary metabolites isolated from the endophytic fungi of Huperzia serrata. Microbial cultivation and fermentation were used to obtain secondary metabolites. Active components were then extracted from the secondary metabolites, and their activities were tracked. Two compounds that were isolated from endophytic fungi of H. serrata were identified and had acetylcholine inhibitory activities. In conclusion, endophytic fungal strains were found in H. serrata that had the same anti-acetylcholinesterase activity. Conclusion We isolated 4 compounds from the endophytic fungus L10Q37, among them S1 and S3 are new compounds. 6 compounds were isolated from LQ2F02, all 6 compounds are new compounds. After tested anti acetylcholinesterase activity, S5 has the best activity. Other compounds' anti acetylcholinesterase activity was not better compared with huperzine A.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Inhibidores de la Colinesterasa / Huperzia / Endófitos Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Electron. j. biotechnol Asunto de la revista: Biotecnologia Año: 2015 Tipo del documento: Artículo País de afiliación: China Institución/País de afiliación: Shanghai University of Traditional Chinese Medicine/CN

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Inhibidores de la Colinesterasa / Huperzia / Endófitos Tipo de estudio: Estudio pronóstico Idioma: Inglés Revista: Electron. j. biotechnol Asunto de la revista: Biotecnologia Año: 2015 Tipo del documento: Artículo País de afiliación: China Institución/País de afiliación: Shanghai University of Traditional Chinese Medicine/CN