Vaccinia core transcription prevents in vitro depolymerization of polyribosomes in rabbit reticulocyte lysate
Braz. j. med. biol. res
;
20(6): 763-6, 1987. ilus
Artículo
en Inglés
| LILACS
| ID: lil-77433
ABSTRACT
When a rabbit reticulocyte lysate is incubated in the presence of vaccina cores, protein synthesis is umpaired at the level of the initiation step and the polyribosomes are depolymerized. However, when the same system is coupled with virus transcription a) protein synthesis is restored, b) the initiation step is not inhibited, and c) the polyribosomes are not disaggregated. A viral factor activated in the absence of virus transcription and not activated when RNA synthesis occurs may be involved in the early mechanism of protein synthesis inhibition by vaccinia virus
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Índice:
LILACS (Américas)
Asunto principal:
Polirribosomas
/
Reticulocitos
/
Transcripción Genética
/
Vaccinia
/
Técnicas In Vitro
/
Inhibidores de la Síntesis de la Proteína
/
Proteínas
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1987
Tipo del documento:
Artículo
/
Congreso y conferencia
/
Documento de proyecto
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