Linfoma de Burkitt en pacientes HIV positivo tratados con quimioterapia intensiva en el Hospital del Salvador entre 2011 y 2014: Protocolo Nacional de Cáncer del Adulto, Chile / Intensive chemotherapy for Burkitt lymphoma in HIV positive patients
Rev. méd. Chile
;
143(12): 1505-1511, dic. 2015. graf, tab
Artículo
en Español
| LILACS
| ID: lil-774434
ABSTRACT
Background:
Burkitt lymphoma has a low incidence, is highly aggressive, may be endemic, sporadic or associated with immunodeficiency and it has a high frequency of extranodal involvement. Overall and relapse free survival in HIV patients is 72 and 71% respectively. However, the current protocol in Chile considers a positive HIV serology as an exclusion criterion for intensive chemotherapy.Aim:
To analyze the response to Burkitt lymphoma treatment among HIV positive patients. Material andMethods:
All HIV positive patients with a Burkitt lymphoma treated using PANDA protocol in a public hospital were analyzed.Results:
Eight male patients aged between 25 and 43 years, 63% in stage IV, were analyzed. All patients received an intensified chemotherapy regime, three of them without Rituximab. Complete remission was achieved in 87%. One patient was refractory to treatment and one patient relapsed at 5 months and died. Overall and relapse free survival were 58 and 60% respectively. All patients had episodes of high risk febrile neutropenia, but it did not cause deaths.Conclusions:
In this group of HIV patients, intensive chemotherapy for Burkitt lymphoma had a high degree of effectiveness with a low relapse rate and high cure rate.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Fracturas Óseas
/
Sarcopenia
Tipo de estudio:
Guía de Práctica Clínica
Límite:
Humanos
País/Región como asunto:
America Central
/
America del Sur
/
Chile
/
El Salvador
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2015
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Hospital del Salvador/CL
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