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Linfoma de Burkitt en pacientes HIV positivo tratados con quimioterapia intensiva en el Hospital del Salvador entre 2011 y 2014: Protocolo Nacional de Cáncer del Adulto, Chile / Intensive chemotherapy for Burkitt lymphoma in HIV positive patients
Puga L, Bárbara; Bustamante K, Katherinne; Molina E, Javiera; Andrade M, Alejandro.
  • Puga L, Bárbara; Hospital del Salvador. Unidad Hematología Intensiva. Santiago. CL
  • Bustamante K, Katherinne; Hospital del Salvador. Unidad Hematología Intensiva. Santiago. CL
  • Molina E, Javiera; Hospital del Salvador. Unidad Hematología Intensiva. Santiago. CL
  • Andrade M, Alejandro; Hospital del Salvador. Unidad Hematología Intensiva. Santiago. CL
Rev. méd. Chile ; 143(12): 1505-1511, dic. 2015. graf, tab
Artículo en Español | LILACS | ID: lil-774434
ABSTRACT

Background:

Burkitt lymphoma has a low incidence, is highly aggressive, may be endemic, sporadic or associated with immunodeficiency and it has a high frequency of extranodal involvement. Overall and relapse free survival in HIV patients is 72 and 71% respectively. However, the current protocol in Chile considers a positive HIV serology as an exclusion criterion for intensive chemotherapy.

Aim:

To analyze the response to Burkitt lymphoma treatment among HIV positive patients. Material and

Methods:

All HIV positive patients with a Burkitt lymphoma treated using PANDA protocol in a public hospital were analyzed.

Results:

Eight male patients aged between 25 and 43 years, 63% in stage IV, were analyzed. All patients received an intensified chemotherapy regime, three of them without Rituximab. Complete remission was achieved in 87%. One patient was refractory to treatment and one patient relapsed at 5 months and died. Overall and relapse free survival were 58 and 60% respectively. All patients had episodes of high risk febrile neutropenia, but it did not cause deaths.

Conclusions:

In this group of HIV patients, intensive chemotherapy for Burkitt lymphoma had a high degree of effectiveness with a low relapse rate and high cure rate.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Fracturas Óseas / Sarcopenia Tipo de estudio: Guía de Práctica Clínica Límite: Humanos País/Región como asunto: America Central / America del Sur / Chile / El Salvador Idioma: Español Revista: Rev. méd. Chile Asunto de la revista: Medicina Año: 2015 Tipo del documento: Artículo País de afiliación: Chile Institución/País de afiliación: Hospital del Salvador/CL

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Fracturas Óseas / Sarcopenia Tipo de estudio: Guía de Práctica Clínica Límite: Humanos País/Región como asunto: America Central / America del Sur / Chile / El Salvador Idioma: Español Revista: Rev. méd. Chile Asunto de la revista: Medicina Año: 2015 Tipo del documento: Artículo País de afiliación: Chile Institución/País de afiliación: Hospital del Salvador/CL