Vitamin A supplementation reduces the Th17-Treg – Related cytokines in obese and non-obese women
Arch. endocrinol. metab. (Online)
;
60(1): 29-35, Feb. 2016. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-774620
ABSTRACT
ABSTRACT Objective The objective of the present study was to investigate the effect of vitamin A supplementation on serum Th17 (IL-6, IL-17, IFNγ) and Treg (TGF-β, IL-10) related cytokines in obese and non-obese women. Subjects and methods In a randomized double blind placebo controlled design, 56 obese women were randomly assigned to receive either an oral dose of 25,000 IU retinyl palmitate or placebo per day for 4 months. Twenty eight ages matched non-obese women were also received vitamin A. At the study entry, anthropometric variables were measured and serum Th17 and Treg related cytokine profile were determined at baseline and 4 months after intervention. Results Significantly higher baseline concentrations of IL-6 were observed in obese compared with non-obese women (P < 0.05). However, the initial concentrations of other cytokines were not significantly different between groups. The mean concentrations of IL-17 and TGF-β were significantly decreased after vitamin A supplementation in non-obese and obese women respectively. Positive relationships between IL-17 and IL-10 (r = 0.42, P < 0.001), TGF-β and IL-17 (r = 0.35, P < 0.001) and between IL-10 and IFN-γ (r = 0.41, P = 0.002) in total participants were also observed. Conclusions The results of the present study showed for the first time that vitamin A supplementation reduces serum concentrations of IL-17 and TGF-β in reproductive age women. Further studies are needed to explore the possible underlying mechanisms.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Vitamina A
/
Vitaminas
/
Citocinas
/
Suplementos Dietéticos
/
Obesidad
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Adulto
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Arch. endocrinol. metab. (Online)
Asunto de la revista:
Endocrinologia
/
Metabolismo
Año:
2016
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Irán
Institución/País de afiliación:
Tabriz University of Medical Sciences/IR
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