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Mutations in the S gene and in the overlapping reverse transcriptase region in chronic hepatitis B Chinese patients with coexistence of HBsAg and anti-HBs
Ding, Feng; Miao, Xi-Li; Li, Yan-Xia; Dai, Jin-Fen; Yu, Hong-Gang.
  • Ding, Feng; Renmin Hospital of Wuhan University. Department of Gastroenterology. CN
  • Miao, Xi-Li; Renmin Hospital of Wuhan University. Department of Gastroenterology. CN
  • Li, Yan-Xia; Renmin Hospital of Wuhan University. Department of Gastroenterology. CN
  • Dai, Jin-Fen; Renmin Hospital of Wuhan University. Department of Gastroenterology. CN
  • Yu, Hong-Gang; Renmin Hospital of Wuhan University. Department of Gastroenterology. CN
Braz. j. infect. dis ; 20(1): 1-7, Jan.-Feb. 2016. tab, graf
Artículo en Inglés | LILACS | ID: lil-776471
ABSTRACT
Abstract Background The mechanism underlying the coexistence of hepatitis B surface antigen and antibodies to HBsAg in chronic hepatitis B patients remains unknown. Aims This research aimed to determine the clinical and virological features of the rare pattern. Methods A total of 32 chronic hepatitis B patients infected by HBV genotype C were included 15 carrying both HBsAg and anti-HBs (group I) and 17 solely positive for HBsAg (group II). S gene and reverse transcriptase region sequences were amplified, sequenced and compared with the reference sequences. Results The amino acid variability within major hydrophilic region, especially the “a” determinant region, and within reverse transcriptase for regions overlapping the major hydrophilic region in group I is significantly higher than those in group II. Mutation sI126S/T within the “a” determinant was the most frequent change, and only patients from group I had the sQ129R, sG130N, sF134I, sG145R amino acid changes, which are known to alter immunogenicity. Conclusions In chronic patients, the concurrent HBsAg/anti-HBs serological profile is associated with an increased aa variability in several key areas of HBV genome. Additional research on these genetic mutants are needed to clarify their biological significance for viral persistence.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Proteínas del Envoltorio Viral / Virus de la Hepatitis B / ADN Polimerasa Dirigida por ARN / Hepatitis B Crónica / Anticuerpos contra la Hepatitis B / Antígenos de Superficie de la Hepatitis B Límite: Adulto / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Braz. j. infect. dis Asunto de la revista: Enfermedades Transmisibles Año: 2016 Tipo del documento: Artículo / Documento de proyecto País de afiliación: China Institución/País de afiliación: Renmin Hospital of Wuhan University/CN

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Proteínas del Envoltorio Viral / Virus de la Hepatitis B / ADN Polimerasa Dirigida por ARN / Hepatitis B Crónica / Anticuerpos contra la Hepatitis B / Antígenos de Superficie de la Hepatitis B Límite: Adulto / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Braz. j. infect. dis Asunto de la revista: Enfermedades Transmisibles Año: 2016 Tipo del documento: Artículo / Documento de proyecto País de afiliación: China Institución/País de afiliación: Renmin Hospital of Wuhan University/CN