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Influence of supragingival biofilm control and smoking habit on Interleukin-1β concentration
GOMES, Sabrina Carvalho; ABASCAL, Carolina Coradini; HAAS, Alex Nogueira; ANGST, Patricia Daniela Melchiors; OPPERMANN, Rui Vicente; MARCANTONIO, Rosemary Adriana Chierici.
  • GOMES, Sabrina Carvalho; Universidade Federal do Rio Grande do Sul. Dental School. Department of Periodontology. Porto Alegre. BR
  • ABASCAL, Carolina Coradini; Universidade Federal do Rio Grande do Sul. Dental School. Department of Periodontology. Porto Alegre. BR
  • HAAS, Alex Nogueira; Universidade Federal do Rio Grande do Sul. Dental School. Department of Periodontology. Porto Alegre. BR
  • ANGST, Patricia Daniela Melchiors; Universidade Federal do Rio Grande do Sul. Dental School. Department of Periodontology. Porto Alegre. BR
  • OPPERMANN, Rui Vicente; Universidade Federal do Rio Grande do Sul. Dental School. Department of Periodontology. Porto Alegre. BR
  • MARCANTONIO, Rosemary Adriana Chierici; Universidade Federal do Rio Grande do Sul. Dental School. Department of Periodontology. Porto Alegre. BR
Braz. oral res. (Online) ; 29(1): 1-8, 2015. tab, ilus
Artículo en Inglés | LILACS | ID: lil-777156
ABSTRACT
This investigation compared gingival crevicular fluid (GCF) interleukin-1β (IL-1β) concentrations in periodontitis patients subjected to a strict supragingival biofilm control (Supra) for 6 months. Never-smokers (23) and smokers (n = 20; 19.6 ± 11.8 cigarettes/day) moderate-to-severe chronic periodontitis patients underwent a 6 months period of supragingival control with weekly recall visits. Periodontal probing depth (PPD), bleeding on probing (BOP) and GCF samples (from different PPD category sites 3-5 mm and 6–10 mm) were obtained at the baseline, 30, and 180 days. IL-1β was assessed by enzyme-linked immunosorbent assay. Generalized estimating equations were used to fit prediction models of IL-1β changes, considering the dependence between the examinations, and using only data from experimental sites. Overall IL-1β concentrations decreased from 3.2 pg/µL to 1.9 pg/µL. Higher baseline IL-1β concentrations were associated with higher baseline PPD values in both groups. There were no differences in IL-1β concentrations between never-smokers and smokers over time for any PPD category. Higher baseline PPD values and the presence of BOP on day 180 were significantly associated with higher IL-1β concentrations. A strict Supra regimen reduced IL-1β concentrations over time in periodontitis patients. The benefits observed for smokers underline the importance of oral hygiene measures, even considering the presence of this important risk factor.
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Periodontitis / Fumar / Líquido del Surco Gingival / Biopelículas / Interleucina-1beta Tipo de estudio: Estudio de etiología / Estudio pronóstico Límite: Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Braz. oral res. (Online) Asunto de la revista: Odontología Año: 2015 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal do Rio Grande do Sul/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Periodontitis / Fumar / Líquido del Surco Gingival / Biopelículas / Interleucina-1beta Tipo de estudio: Estudio de etiología / Estudio pronóstico Límite: Adulto / Femenino / Humanos / Masculino Idioma: Inglés Revista: Braz. oral res. (Online) Asunto de la revista: Odontología Año: 2015 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal do Rio Grande do Sul/BR