Glycemia and immunohistochemical changes in the endocrine pancreas of the turtle Chrysemys dorbigni treated with streptozotocin
Braz. j. med. biol. res
;
22(8): 1033-7, 1989. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-77752
ABSTRACT
The diabetogenic action of streptozotocin (SZ) was inbestigated in the turtle Chrysemys dorbigni after a 1-or 14-day fast. SZ (130 or 250 mg/Kg) was inected intravenously, and blood glucose and plasma insulin were measured. Pancreatic endocrine cells were stained immunohistochemically by the immunoperoxidase avidin-biotin-peroxidase complex method. Only 14% of the SZ-treated turtles showed hyperglycemia. Prolonged fasting did not increase the percentage of hyperglycemic animals. In control turtles, insulin (ß-, glucagon (alfa)-and somatostatin (delta)-immunoreactive cells were detected in increasing order of frequency. The qualitative changes seen in cells from the hyperglycemic SZ-treated turtles were more evident in ß and delta cells
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Índice:
LILACS (Américas)
Asunto principal:
Glucemia
/
Islotes Pancreáticos
/
Estreptozocina
/
Insulina
Tipo de estudio:
Investigación cualitativa
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1989
Tipo del documento:
Artículo
/
Documento de proyecto
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