Human leucocyte antigen profile in patients with aids and cytomegalovirus retinitis with and without macular involvement
Clin. biomed. res
;
35(1): 14-19, 2015. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-780281
ABSTRACT
Cytomegalovirus retinitis is one of the ocular manifestations of AIDS. The objective of the present study was to determine possible associations of class I and II HLA antigens and alleles in patients with AIDS and cytomegalovirus retinitis (CMV-R) with and without macular involvement. Method:
The study population consisted of 22 patients with AIDS and CMV-R with macular involvement (Group I), 19 patients with AIDS and CMV-R without macular involvement (Group II), and 202 individuals with negative serology for human immunodeficiency virus (Group III - control). Class I HLA antigens were typed by classical serology. Class II alleles were identified using sequence-specific oligonucleotide primers hybridized with amplified DNA.Results:
HLA-DRB1*14 and HLA-DRB1*10 specificities were more frequent among patients with macular involvement, possibly indicating greater susceptibility to this condition. In contrast, the HLA-B35 antigen may be associated with protection against macular involvement since it was significantly more frequent among patients without this involvement.Conclusions:
The HLA-DRB1*14 and HLA-DRB1*10 alleles may favor the development of CMV-R with macular involvement, whereas the HLA-B35 subtype may be associated with protection against macular involvement...
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Infecciones Oportunistas Relacionadas con el SIDA
/
Retinitis por Citomegalovirus
Límite:
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Clin. biomed. res
Asunto de la revista:
Medicina
Año:
2015
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Faculty of Medicine/BR
/
Laboratory of Molecular Immunology/BR
/
University of São Paulo/BR
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