Procalcitonin determined at emergency department as an early indicator of progression to septic shock in patient with sepsis associated with ureteral calculi
Int. braz. j. urol
;
42(2): 270-276, Mar.-Apr. 2016. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-782867
ABSTRACT
ABSTRACT Introduction:
To investigate the role of initial procalcitonin (PCT) level as an early predictor of septic shock for the patient with sepsis induced by acute pyelonephritis (APN) secondary to ureteral calculi. Materials andMethods:
The data from 49 consecutive patients who met criteria of sepsis due to APN following ureteral stone were collected and divided into two groups with (n=15) or without (n=34) septic shock. The clinical variables including PCT level for this outcome were retrospectively compared by univariate analysis, followed by multivariable logistic regression model.Results:
All subjects had hydronephrosis, and were hospitalized with the mean of 11.8 days (3–42 days). The mean size of the ureteral stones was 7.5mm (3–30mm), and 57% were located in upper ureter. At univariate analysis, patients with septic shock were significantly older, a higher proportion had hypertension, lower platelet count and serum albumin level, higher CRP and PCT level, and higher positive blood culture rate. Multivariate models indicated that lower platelet count and higher PCT level are independent risk factors (p=0.043 and 0.046, respectively). In ROC curve, the AUC was significantly wider in PCT (0.929), compared with the platelet count (0.822, p=0.004). At the cut-off of 0.52ng/mL, the sensitivity and specificity were 86.7% and 85.3%.Conclusion:
Our study demonstrated elevated initial PCT levels as an early independent predictor to progress into septic shock in patients with sepsis associated with ureteral calculi.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Pielonefritis
/
Choque Séptico
/
Calcitonina
/
Cálculos Ureterales
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Int. braz. j. urol
Asunto de la revista:
Urología
Año:
2016
Tipo del documento:
Artículo
País de afiliación:
Corea del Sur
Institución/País de afiliación:
Yeungnam University/KR
Similares
MEDLINE
...
LILACS
LIS