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Effect of Otostegia persica extract on ischemia/reperfusion induced renal damage in diabetic rats. A biochemical study
Takhtfooladi, Mohammad Ashrafzadeh; Asghari, Ahmad; Hoseinzadeh, Hesam aldin; Mokhtari, Farahnaz.
  • Takhtfooladi, Mohammad Ashrafzadeh; Islamic Azad University. Tehran. IR
  • Asghari, Ahmad; Islamic Azad University. Tehran. IR
  • Hoseinzadeh, Hesam aldin; Islamic Azad University. Tehran. IR
  • Mokhtari, Farahnaz; Islamic Azad University. Tehran. IR
Acta cir. bras ; 31(6): 417-421, tab
Artículo en Inglés | LILACS | ID: lil-785013
ABSTRACT
ABSTRACT

PURPOSE:

To evaluate the effect of Otostegia persica (O. persica) extract on renal damage induced by ischemia/reperfusion (I/R) in diabetic rats.

METHODS:

Forty-eight rats were subjected to right nephrectomy; then, they were allocated into six groups Sham; Diabetic sham; I/R; Diabetic I/R; I/R+O. persica; Diabetic I/R+O. persica. Diabetes was induced by streptozotocin (200 mg/kg, i.p.). O. persica (300 mg/kg/day, p.o) was administered for 2 weeks. On the 15th day, ischemia was induced in left kidney for 60 min, followed by reperfusion for 24h. Renal functional and biochemical markers were estimated.

RESULTS:

I/R in both normal and diabetic rats, induced a significant elevation in serum levels of urea and creatinine (p<0.05). Renal I/R induced a significant increase of malondialdehyde, myeloperoxidase and nitric oxide concentrations associated with significant reduction in superoxide dismutase and catalase activities in comparison with the sham group (p<0.05). Diabetic rats that underwent renal I/R exhibited a significant increase in all the studied parameters with a reduction in the antioxidant enzymes as compared to nondiabetic rats (p<0.05). These deleterious effects associated with renal I/R were improved by the treatment with O. persica (p<0.05).

CONCLUSION:

Otostegia persica pretreatment protected the renal injury from ischemia-reperfusion in diabetic rats.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Extractos Vegetales / Daño por Reperfusión / Lamiaceae / Diabetes Mellitus Experimental / Antioxidantes Límite: Animales Idioma: Inglés Revista: Acta cir. bras Asunto de la revista: Cirugía General / Procedimentos Cir£rgicos Operat¢rios Año: 2016 Tipo del documento: Artículo País de afiliación: Irán Institución/País de afiliación: Islamic Azad University/IR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Extractos Vegetales / Daño por Reperfusión / Lamiaceae / Diabetes Mellitus Experimental / Antioxidantes Límite: Animales Idioma: Inglés Revista: Acta cir. bras Asunto de la revista: Cirugía General / Procedimentos Cir£rgicos Operat¢rios Año: 2016 Tipo del documento: Artículo País de afiliación: Irán Institución/País de afiliación: Islamic Azad University/IR