Protective effect of metformin on testicular ischemia/reperfusion injury in rats
Acta cir. bras
;
31(6): 411-416, tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-785016
ABSTRACT
ABSTRACT PURPOSE:
To investigate the protective effect of metformin on testicular ischemia/reperfusion (I/R) injury in rats.METHODS:
Eighteen adult male Wistar rats were randomly divided into three experimental groups (n=6), as follows Sham, I/R, and Metformin. 1-hour ischemia was induced by the left testicular artery and vein clipping followed by 7 days of reperfusion. Metformin (100 mg/kg) was administrated orally for 7 days via oral gavage after ischemic period. At the end of trial, the left testis was removed for histological analysis and oxidative stress measurement.RESULTS:
I/R reduced superoxide dismutase (SOD) activities and testicular Johnsen's scores accompanied by an elevation in malondialdehyde (MDA) and myeloperoxidase (MPO) levels in comparison with the sham group (P < 0.05). Compared to I/R group, metformin restored testicular Johnsen's scores, SOD activity, MDA and MPO levels (P < 0.05).CONCLUSION:
Metformin has a protective effect against I/R injury on the testis.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Testículo
/
Daño por Reperfusión
/
Sustancias Protectoras
/
Metformina
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2016
Tipo del documento:
Artículo
País de afiliación:
Irán
Institución/País de afiliación:
Islamic Azad University/IR
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