Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma
Clinics
;
71(6): 315-319, tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-787421
ABSTRACT
OBJECTIVE:
To evaluate the prognostic significance of microvessel density and p53 expression in pancreatic cancer.METHODS:
Between 2008 and 2012, 49 patients with pancreatic adenocarcinoma underwent resection with curative intention. The resected specimens were immunohistochemically stained with anti-p53 and anti-CD34 antibodies. Microvessel density was assessed by counting vessels within ten areas of each tumoral section a highpower microscope.RESULTS:
The microvessel density ranged from 21.2 to 54.2 vessels/mm2. Positive nuclear staining for p53 was found in 20 patients (40.6%). The overall median survival rate after resection was 24.1 months and there were no differences in survival rates related to microvessel density or p53 positivity. Microvessel density was associated with tumor diameter greater than 3.0 cm and with R0 resection failure.CONCLUSIONS:
Microvessel density was associated with R1 resection and with larger tumors. p53 expression was not correlated with intratumoral microvessel density in pancreatic adenocarcinoma.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Neoplasias Pancreáticas
/
Proteína p53 Supresora de Tumor
/
Carcinoma Ductal Pancreático
/
Microvasos
Tipo de estudio:
Estudio pronóstico
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2016
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de São Paulo/BR
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