Effect of aqueous extract of the Vigna angularis in rats subjected to an experimental model of moderate chronic kidney disease
Acta cir. bras
;
31(8): 527-532, Aug. 2016. graf
Artículo
en Inglés
| LILACS
| ID: lil-792410
ABSTRACT
ABSTRACT PURPOSE:
To evaluate the effect of the aqueous extract of the Vigna angularis, popularly known as "Azuki beans", in rats subjected to an experimental model of moderate chronic kidney disease.METHODS:
Thirty rats underwent two surgeries - Ormrod and Miller (1980) - to obtain Moderate Chronic Kidney Disease (CKD-M). The animals were randomized into 3 groups. Group 1 (Control) distilled water. Group 2 (Azuki) Vigna angularis 5% aqueous extract. Group 3 (Treatment) 10mg/kg of enalapril maleate. The rats received their respective treatments for 14 days.RESULTS:
The treatment with azuki beans produced an increase in urine output from the second day until the end of the experiment compared to the Control groups (p<0.01) and Treatment (p<0.05). The treatment with azuki also produced significant reductions in the levels of glucose, triglycerides, VLDL, uric acid, Alanine aminotransferase (p<0.05), urea and serum creatinine (p<0.01), besides having produced a significant increase in the levels of HDL when compared to the Control group.CONCLUSION:
Treatment with Azuki beans produced improvements in the parameters of renal function and significantly reduced glucose levels, triglycerides, VLDL, alanine aminostransferase, uric acid and creatinine, besides having produced a significant increase in the levels of HDL in rats submitted to a model of moderate chronic kidney disease.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Extractos Vegetales
/
Insuficiencia Renal Crónica
/
Vigna
/
Fitoterapia
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2016
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Medical School of Itajubá/BR
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