The beneficial effects of Montelukast against 2 3 7 8 tetrachlorodibenzo dioxin toxicity in female reproductive system in rats
Acta cir. bras
; 31(8): 557-563, Aug. 2016. tab, graf
Article
en En
| LILACS
| ID: lil-792413
Biblioteca responsable:
BR1.1
ABSTRACT
ABSTRACT PURPOSE:
To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis.METHODS:
Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed.RESULTS:
The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment.CONCLUSION:
The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.Palabras clave
Texto completo:
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Índice:
LILACS
Asunto principal:
Ovario
/
Quinolinas
/
Estrés Oxidativo
/
Dibenzodioxinas Policloradas
/
Acetatos
/
Antioxidantes
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2016
Tipo del documento:
Article