Dysfunctional hyperpolarization-activated cyclic nucleotide-gated ion channels in cardiac diseases
Rev. bras. cir. cardiovasc
;
31(2): 203-206, Mar.-Apr. 2016.
Artículo
en Inglés
| LILACS
| ID: lil-792650
ABSTRACT
Abstract Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are reverse voltage-dependent, and their activation depends on the hyperpolarization of the membrane and may be directly or indirectly regulated by the cyclic adenosine monophosphate (cAMP) or other signal-transduction cascades. The distribution, quantity and activation states of HCN channels differ in tissues throughout the body. Evidence exhibits that HCN channels play critical roles in the generation and conduction of the electrical impulse and the physiopathological process of some cardiac diseases. They may constitute promising drug targets in the treatment of these cardiac diseases. Pharmacological treatment targeting HCN channels is of benefit to these cardiac conditions.
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LILACS (Américas)
Asunto principal:
Canales Regulados por Nucleótidos Cíclicos Activados por Hiperpolarización
/
Cardiopatías
Límite:
Humanos
Idioma:
Inglés
Revista:
Rev. bras. cir. cardiovasc
Asunto de la revista:
Cardiología
/
Cirugía General
Año:
2016
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
China Medical University/CN
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